Anti-CD8 Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:3000.
交叉反應(yīng)Mouse

產(chǎn)品型號：K106402P

更新時間：2022-08-15

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標簽抗體血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗內(nèi)參抗體膠體金標記二抗生物素化二抗 RBITC熒光標記抗體二抗 FITC熒光標記抗體二抗免疫血清二抗純化抗體二抗 HRP標記二抗免疫球蛋白抗原IgG二抗

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Anti-CD8 Polyclonal Antibody

英文名稱	Anti-CD8 Polyclonal Antibody
宿主	Rabbit
別名	CD8A;MAL;Leu2;p32;OKT8 T cell antigen
應(yīng)用	WB
稀釋比例	WB 1:3000.
交叉反應(yīng)	Mouse
蛋白分子量	28kDa
Gene ID	925
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human CD8
性狀	液體
Public Immunogen Range	A synthetic peptide of human CD8
Subcellular Locations	Cell membrane
Swiss Prot	P01732
克隆類型	Polyclonal Antibody
背景資料	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.