Anti-GRP78 Polyclonal Antibody
應用 WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應Human Mouse Rat

產品型號：K106525P

更新時間：2022-08-15

廠商性質：生產廠家

訪問量：1110

服務熱線

010-50973130

立即咨詢

產品分類

PRODUCT CLASSIFICATION

產品介紹

Anti-GRP78 Polyclonal Antibody

英文名稱	Anti-GRP78 Polyclonal Antibody
宿主	Rabbit
別名	BIP;GRP78;HEL-S-89n;MIF2
應用	WB IHC
稀釋比例	WB 1:2000-5000.IHC 1:50-200.
交叉反應	Human Mouse Rat
蛋白分子量	70kDa
Gene ID	3309
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human GRP78
性狀	液體
Public Immunogen Range	A synthetic peptide of human GRP78
Subcellular Locations	Cytoplasm Endoplasmic reticulum lumen Melanosome
Swiss Prot	P11021
克隆類型	Polyclonal Antibody
背景資料	The 78 kDa glucose regulated protein/BiP (GRP78) belongs to the family of ~70 kDa heat shock proteins (HSP 70). GRP78 is a resident protein of the endoplasmic reticulum (ER) and may associate transiently with a variety of newly synthesized secretory and membrane proteins or permanently with mutant or defective proteins that are incorrectly folded, thus preventing their export from the ER lumen. GRP78 is a highly conserved protein that is essential for cell viability. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the C terminus of GRP78 and other resident ER proteins including glucose regulated protein 94 (GRP 94) and protein disulfide isomerase (PDI). The presence of carboxy terminal KDEL appears to be necessary for retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.